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and Data Communication. Vol. 4 No. 1, pp. 17-20, 2016. [4] Güller, M.; Uygun, Y.; Noche, B. 2015. „Simulation-based Optimization for a Capacitated Multi- Echelon Production-Inventory System“. In: Journal [...] eine ABC-Analyse. Typisch sind Stückzahlgrenzen von 70% der kumulierten Menge für A-Teile, 20% der kumulierten Menge für B- Teile und 10% der kumulierten Menge für C-Teile. Hintergrund der Analyse ist die [...] https://doi.org/10.1057/s41273-017-0061-1, pp. 1-14, 2017. [3] Karakaya, E.; Uygun, Y.; Güller, M. & Kuhn, A. 2016. „Development of an Agent-based Simulation for the Cellular Transport System and Scenario-based …

immunotherapy treatments. A major immune evasion mechanism observed in melanoma is the modulation of the HLA-I-APM. This can be a result of a B2M mutation or deletion leading to a loss of HLA-I expression [...] validated a reduced expression of TUSC7 in cancer samples and a correlation with poor prognosis across multiple cancer types167,168. In colorectal cancer a ceRNA activity towards miR-23b, a target of [...] cells spread through the bloodstream to a distant site, reverting to a proliferative cell state to form a metastasis. This cycle of phenotype switch accompanied with a change in the gene signature expression …