k 1 /ß -a k ti n Pyr/Lac (mM) Glycerol (mM) ṦṦṦ ṦṦṦṦ ṦṦṦ ṦṦ Ṧ ṦṦṦ FM 1/10 2/20 5/50 FM 1 2 5 0.0 0.5 1.0 1.5 G6pc G 6 p c /ɓ -a k ti n Pyr/Lac (mM) Glycerol (mM) G6pc B-aktin Pck1 B-aktin A B Figure 14: [...] x -f o ld c h a n g e Alanine (mM) Glutamine (mM) ṦṦṦ Ṧ Ṧ FM 1 5 10 FM 1 5 10 0.0 0.5 1.0 1.5 2.0 2.5 G6pc x -f o ld c h a n g e Alanine (mM) Glutamine (mM) Pck1 B-aktin G6pc B-aktin A B Figure 15: Western [...] ṦṦ no s ub st ra te A la + 0 µM O x A la + 5 0 µM O x A la + 1 00 µ M O x A la + 30 0 µM O x A la + 1 m M O x 0 100 200 300 G lu c o s e ( % ) Gluconeogenesis from Alanine Ṧ Ṧ ṦṦ A B Figure 18: Glucose …

A PRACTICAL OVERVIEW OF QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP

<FEFF3053306e8a2d5b9a306f30019ad889e350cf5ea6753b50cf3092542b308000200050004400460020658766f830924f5c62103059308b3068304d306b4f7f75283057307e30593002537052376642306e753b8cea3092670059279650306b4fdd3064305 [...] 7300690061006b00690072006a006f006a0061002c0020006a006f006900640065006e002000740075006c006f0073007400750073006c00610061007400750020006f006e0020006b006f0072006b006500610020006a00610020006b00750076006100 [...] 7-62. Decker M, Arand M, Cronin A. Mammal- ian epoxide hydrolases in xenobiotic me- tabolism and signalling. Arch Toxicol 2009;83:297-318. Dewa Y, Nishimura J, Muguruma M, Jin M, Kawai M, Saegusa Y et …